abstract：BACKGROUND:CYP2D6 gene encoding CYP2D6 enzyme belonging to the cytochrome P450 system has aroused long attention being a candidate gene for Alzheimer's disease (AD), but the results remain inconsistent and underpowered. OBJECTIVES:To investigate the contradictory results, the effect of single CYP2D6 polymorphism- CYP2...

journal_title：Journal of the neurological sciences

authors： Lu Y,Qin X,Li S,Zhang X,He Y,Peng Q,Deng Y,Wang J,Xie L,Li T,Zeng Z

更新日期：2014-08-15 00:00:00

abstract：:We studied the limitations to early diagnosis in amyotrophic lateral sclerosis (ALS). The diagnostic process was assessed in 120 consecutive patients, including onset, interval to diagnosis, investigations, specialist assessment and pre-diagnostic management. Times from onset to first consultation (T1), second consult...

journal_title：Journal of the neurological sciences

authors： Nzwalo H,de Abreu D,Swash M,Pinto S,de Carvalho M

更新日期：2014-08-15 00:00:00

abstract：BACKGROUND:Although predominantly reported in patients with status epilepticus, periictal MRI abnormalities have been reported in patients with a single or a cluster of seizures. Clinicians are often presented with a dilemma concerning the features of MRI abnormalities induced by a single or a cluster of seizures, as t...

journal_title：Journal of the neurological sciences

authors： Xiang T,Li G,Liang Y,Zhou J

更新日期：2014-08-15 00:00:00

abstract：BACKGROUND:Headache burden is not adequately explored in Africa. Here, we measured weighted migraine prevalence from community-based studies in Africa. METHODS:PubMed search was employed using terms 'headache in Africa' AND/OR 'migraine in Africa' for published literature from 1970 until January 31, 2014. PRISMA was a...

journal_title：Journal of the neurological sciences

authors： Woldeamanuel YW,Andreou AP,Cowan RP

更新日期：2014-07-15 00:00:00

abstract：:Lewis-Sumner syndrome (LSS) is considered a variant of chronic inflammatory demyelinating polyneuropathy (CIDP), which is more frequently described with exclusive upper limb involvement. The diagnosis of LSS is clinical and electrophysiological. However, these are not always obvious and in view of its rarity, the diag...

journal_title：Journal of the neurological sciences

authors： Rajabally YA,Knopp MJ,Martin-Lamb D,Morlese J

更新日期：2014-07-15 00:00:00

abstract：BACKGROUND AND AIMS:Subacute combined degeneration (SACD) of the spinal cord, characterized by degeneration of lateral and posterior columns, is often found in vitamin B12 deficiency. Our aim was to look for sensitivity of imaging in depicting the spinal cord abnormality in vitamin B12 deficient patients and to find an...

journal_title：Journal of the neurological sciences

authors： Jain KK,Malhotra HS,Garg RK,Gupta PK,Roy B,Gupta RK

更新日期：2014-07-15 00:00:00

abstract：BACKGROUND:Chorea is a common presenting feature of metabolic disorders, including nonketotic hyperglycemia in patients with type 2 diabetes mellitus, but rarely has been reported in diabetic ketoacidosis, hypothyroidism and vitamin B12 deficiency. METHODS:Review the literature for reported cases of chorea as a presen...

journal_title：Journal of the neurological sciences

authors： Yassin AM,Shroff S,Patel SD,Paker AM,Berman MA,Jackson GR

更新日期：2014-07-15 00:00:00

abstract：BACKGROUND:Contactin-associated protein 2 (Caspr2) antibody is a neuronal surface antibody (NSAb) capable of causing disorders involving central and peripheral nervous systems (PNS). Thymoma can be found in patients with Caspr2 antibodies and is most frequently associated with PNS symptoms. Myasthenia gravis can be fou...

journal_title：Journal of the neurological sciences

authors： Lee CH,Lin JJ,Lin KJ,Chang BL,Hsieh HY,Chen WH,Lin KL,Fung HC,Wu T

更新日期：2014-06-15 00:00:00

abstract：BACKGROUND:Mental disorders are commonly observed among surgically treated patients with hypertensive intracerebral hemorrhage (HICH), leading to serious negative impacts on the patient's treatment, rehabilitation, and prognosis. The study aimed to establish the prevalence rates and risk factors for mental disorders fo...

journal_title：Journal of the neurological sciences

authors： Li F,Chen QX

更新日期：2014-06-15 00:00:00

abstract：:Opsoclonus-myoclonus syndrome (OMS) is characterized by opsoclonus and arrhythmic-action myoclonus that predominantly involves the trunk, limbs, and head. Human herpes virus-6 (HHV-6) can rarely cause encephalitis in immunocompetent children and adults. Here we report on a case of OMS associated with HHV-6 rhomboencep...

journal_title：Journal of the neurological sciences

authors： Belcastro V,Piola M,Binda S,Santoro D,Rezzonico M,Arnaboldi M

更新日期：2014-06-15 00:00:00

abstract：BACKGROUND AND PURPOSE:It is well known that inflammation influence chronic subdural hematoma (CSDH) formation to a large extent. Atorvastatin has pleiotropic effects on restraining inflammation and promoting angiogenesis besides its cholesterol-lowering function. Hence, atorvastatin may induce anti-inflammation effect...

journal_title：Journal of the neurological sciences

authors： Li T,Wang D,Tian Y,Yu H,Wang Y,Quan W,Cui W,Zhou L,Chen J,Jiang R,Zhang J

更新日期：2014-06-15 00:00:00

abstract：METHODS:The nine hole peg test (9HPT) is an emerging outcome measure in clinical trials in multiple sclerosis (MS). In this study we investigated how performance on the 9HPT at baseline is related to annualized direct MS related cost. METHODS:We enrolled patients with a definite diagnosis of MS from two Canadian MS ce...

journal_title：Journal of the neurological sciences

authors： Koch MW,Murray TJ,Fisk J,Greenfield J,Bhan V,Jacobs P,Brown M,Metz LM

更新日期：2014-06-15 00:00:00

abstract：:A number of diseases exhibit neurodegeneration with/without additional symptoms such as immunodeficiency, increased cancer risk, and microcephalus. Ataxia telangiectasia and Nijmegen breakage syndrome, for example, develop as a result of mutations in genes involved in the DNA damage response. However, such diseases ca...

journal_title：Journal of the neurological sciences

authors： Hasegawa S,Imai K,Yoshida K,Okuno Y,Muramatsu H,Shiraishi Y,Chiba K,Tanaka H,Miyano S,Kojima S,Ogawa S,Morio T,Mizutani S,Takagi M

更新日期：2014-05-15 00:00:00

abstract：BACKGROUND:Myosin-IIB is a non-muscle isoform in the brain with increased expression in the brains of diabetic rats. Chronic hyperglycemia caused by diabetes can impair learning and memory. Oral hypoglycemic agents such as glibenclamide have been used to control hyperglycemia. We report changes in the expression and di...

journal_title：Journal of the neurological sciences

authors： da Costa AV,Calábria LK,de Souza Santos P,Goulart LR,Espindola FS

更新日期：2014-05-15 00:00:00

abstract：OBJECTIVE:This study used reaction time (RT) as an objective marker of cognitive fatigue and fatigability in patients with multiple sclerosis (MS). METHOD:RT was measured in fifteen healthy controls and in thirty MS patients with cognitive fatigue identified with the Fatigue Scale for Motor and Cognitive Function (FSM...

journal_title：Journal of the neurological sciences

authors： Neumann M,Sterr A,Claros-Salinas D,Gütler R,Ulrich R,Dettmers C

更新日期：2014-05-15 00:00:00

abstract：IMPORTANCE:Natalizumab was approved in 2004 by the US Food and Drug Administration (US-FDA) for treatment of multiple sclerosis (MS), however it was temporarily withdrawn after its use was associated with progressive multifocal leukoencephalopathy (PML). Other reported adverse events have included melanoma, primary cen...

journal_title：Journal of the neurological sciences

authors： Valenzuela RM,Pula JH,Garwacki D,Cotter J,Kattah JC

更新日期：2014-05-15 00:00:00

abstract：BACKGROUND:Recently, PRRT2 gene mutations have been identified as a causative factor of paroxysmal kinesigenic dyskinesia (PKD). However, evidence is still lacking with respect to the genotype to phenotype correlation in PKD patients. METHODS:We recruited a cohort of PKD patients with or without PRRT2 mutations for th...

journal_title：Journal of the neurological sciences

authors： Mao CY,Shi CH,Song B,Wu J,Ji Y,Qin J,Li YS,Wang JJ,Shang DD,Sun SL,Xu YM

更新日期：2014-05-15 00:00:00

abstract：:A boy, who had shown muscle weakness and hypotonia from early childhood and fiber type disproportion (FTD) with no dystrophic changes on muscle biopsy, was initially diagnosed as having congenital fiber type disproportion (CFTD). Subsequently, he developed cardiac conduction blocks. We reconsidered the diagnosis as po...

journal_title：Journal of the neurological sciences

authors： Kajino S,Ishihara K,Goto K,Ishigaki K,Noguchi S,Nonaka I,Osawa M,Nishino I,Hayashi YK

更新日期：2014-05-15 00:00:00

abstract：BACKGROUND:There has been increased interest in objectively quantifying time spent in moderate-to-vigorous physical activity (MVPA) using accelerometry as an outcome among persons with multiple sclerosis (MS). This requires development of a cut-point for interpreting the rate of accelerometer output based on its associ...

journal_title：Journal of the neurological sciences

authors： Sandroff BM,Riskin BJ,Agiovlasitis S,Motl RW

更新日期：2014-05-15 00:00:00

abstract：INTRODUCTION:Nerve conduction is often regarded as more sensitive than ultrasonography (US) for diagnosing carpal tunnel syndrome (CTS). The diagnostic value of US derives from median nerve enlargement occurring at both ends of the carpal tunnel resulting in a dumbbell-like swelling from carpal tunnel pressure. An impo...

journal_title：Journal of the neurological sciences

authors： Paliwal PR,Therimadasamy AK,Chan YC,Wilder-Smith EP

更新日期：2014-04-15 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) represents a promising tool for studying and influencing cognition in people with neurodegenerative diseases. This procedure is noninvasive and painless, and it does not require the use of anesthesia or pharmacological substances. In this systematic critical review w...

journal_title：Journal of the neurological sciences

authors： Anderkova L,Rektorova I

更新日期：2014-04-15 00:00:00

abstract：BACKGROUND:Pontine infarcts can be classified into four regions based on the vascular anatomy: anteromedial, anterolateral, lateral and posterior. The purpose of this study was to determine if different etiological mechanisms are responsible for these four types of pontine infarcts. METHODS:We studied consecutive pati...

journal_title：Journal of the neurological sciences

authors： Kobayashi J,Ohara T,Minematsu K,Nagatsuka K,Toyoda K

更新日期：2014-04-15 00:00:00

abstract：BACKGROUND:The epidemiology and pathophysiology of iNPH remain unclear. We aimed to investigate the incidence of iNPH in elderly inhabitants of the community, and to identify how ventriculomegaly develops on brain MRIs and how symptoms develop in iNPH patients. METHODS:In 2000, 350 inhabitants, all 70-year-olds living...

journal_title：Journal of the neurological sciences

authors： Iseki C,Takahashi Y,Wada M,Kawanami T,Adachi M,Kato T

更新日期：2014-04-15 00:00:00

abstract：:Acute cortical lesions rarely cause vertigo. We report a 51-year-old patient presenting with an acute vestibular syndrome including spontaneous vertigo and nystagmus, lateropulsion and nausea due to middle cerebral artery infarction. The central origin of the acute vestibular syndrome was revealed by a normal head imp...

journal_title：Journal of the neurological sciences

authors： von Brevern M,Süßmilch S,Zeise D

更新日期：2014-04-15 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of disability or death worldwide, especially in the young. Thus, effective medication with few side effects needs to be developed. This work aimed to explore the potential benefits of formononetin (FN) on TBI rodent model and to discuss the regarding mechanism. These findi...

journal_title：Journal of the neurological sciences

authors： Li Z,Dong X,Zhang J,Zeng G,Zhao H,Liu Y,Qiu R,Mo L,Ye Y

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:MS and psoriasis are both autoimmune diseases putatively mediated mainly by T cells. OBJECTIVE:We conducted a case control study to investigate whether patients with MS have a high rate of comorbid psoriasis. METHODS:The cohort consisted of 214 consecutive MS patients and a control group of 192 consecutive...

journal_title：Journal of the neurological sciences

authors： Fellner A,Dano M,Regev K,Mosek A,Karni A

更新日期：2014-03-15 00:00:00

abstract：:The 3243A>G mutation of mtDNA usually is associated with MELAS syndrome. Here we report a patient with the 3243A>G mutation presenting only recurrent muscle fatigue and elevated levels of serum creatine kinase (CK). The mother of the proband was referred to us for type 2 diabetes mellitus, muscle pain and sensorineura...

journal_title：Journal of the neurological sciences

authors： Rubegni A,Cardaioli E,Chini E,Da Pozzo P,Battisti C,Malandrini A,Federico A

更新日期：2014-03-15 00:00:00

abstract：OBJECTIVES:There is insufficient data on the efficacy of intravenous immunoglobulins (IVIg) as maintenance treatment in myasthenia gravis (MG). We therefore examined response to maintenance IVIg therapy in a cohort of MG patients. METHODS:We reviewed all MG patient files treated with IVIg in our neuro-immunology clini...

journal_title：Journal of the neurological sciences

authors： Hellmann MA,Mosberg-Galili R,Lotan I,Steiner I

更新日期：2014-03-15 00:00:00

abstract：:Variability in the activity and function of serum paraoxonase (PON1) as an antioxidant enzyme involved in vascular disease has been observed. In this study, we investigated the enzyme activity parameters, based on the 192Q/R polymorphism, using the salt stimulation property of PON1 as an important although neglected p...

journal_title：Journal of the neurological sciences

authors： Mahrooz A,Alizadeh A,Gohari G

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:Global cerebral ischemia followed by reperfusion, leads to extensive neuronal damage, particularly the neurons in the hippocampal CA region. Recent studies have demonstrated that pharmacological agents, such as Nigella sativa L. (Ranunculaceae) that is an annual herbaceous flowering plant, given at the time ...

journal_title：Journal of the neurological sciences

authors： Hobbenaghi R,Javanbakht J,Sadeghzadeh Sh,Kheradmand D,Abdi FS,Jaberi MH,Mohammadiyan MR,Khadivar F,Mollaei Y

更新日期：2014-02-15 00:00:00

abstract：OBJECTIVES:Central autonomic impairment is frequent in ischemic stroke at acute or chronic stages. The mechanism by which these symptoms occur in patients with ischemic stroke has not been elucidated. This study sought to investigate cardiovascular autonomic function in patients with different subtypes of post-acute is...

journal_title：Journal of the neurological sciences

authors： Xiong L,Leung HW,Chen XY,Leung WH,Soo OY,Wong KS

更新日期：2014-02-15 00:00:00

abstract：:The optimal treatment for secondary prevention in patients who have a patent foramen ovale (PFO) and history of cryptogenic stroke is still uncertain and controversial. In view of this, we performed a systematic review of randomized controlled trials (RCTs) to investigate whether PFO closure was superior to medical th...

journal_title：Journal of the neurological sciences

authors： Chen L,Luo S,Yan L,Zhao W

更新日期：2014-02-15 00:00:00

abstract：:The study is designed to assess the oxidative stress intensity in erythrocytes obtained from patients in different clinical phenotypes of neuroinflammation, defined as clinically isolated syndrome (CIS) and relapsing-remitting multiple sclerosis (RRMS). Advanced oxidation protein products (AOPP), malondialdehyde (MDA)...

journal_title：Journal of the neurological sciences

authors： Ljubisavljevic S,Stojanovic I,Cvetkovic T,Vojinovic S,Stojanov D,Stojanovic D,Stefanovic N,Pavlovic D

更新日期：2014-02-15 00:00:00

abstract：INTRODUCTION:Whether motor neuron diseases (MNDs) can be considered in some cases of paraneoplastic syndromes is controversial. We report a case of rapidly progressive motor neuronopathy following a diagnosis of breast carcinoma, with a presence of anti-Ri antibodies, and a novel SOD1 gene mutation. OBSERVATION:An 80-...

journal_title：Journal of the neurological sciences

authors： Diard-Detoeuf C,Dangoumau A,Limousin N,Biberon J,Vourc'h P,Andres CR,de Toffol B,Praline J

更新日期：2014-02-15 00:00:00

abstract：BACKGROUND:Progressive multifocal leukoencephalopathy, caused by oligodendrocyte lytic infection by JCVirus, is a growing concern for patients undergoing immune modulatory therapies for treatment of autoimmune diseases, such as multiple sclerosis (MS). The objective of JEMS was to describe the prevalence of anti-JCV an...

journal_title：Journal of the neurological sciences

authors： da Silva AM,Santos ME,Portuguese JEMS Study Investigators.

更新日期：2014-02-15 00:00:00

abstract：BACKGROUND:Fatigue is a common non-motor symptom in Parkinson's disease patients. The reasons for its perception are not completely understood. One suggested possibility might be that perceived fatigue is related with abnormal interpretation of somatic symptoms. It has been described that somatic markers misinterpretat...

journal_title：Journal of the neurological sciences

authors： Sáez-Francàs N,Hernández-Vara J,Corominas-Roso M,Alegre J,Jacas C,Casas M

更新日期：2014-02-15 00:00:00

abstract：:The purpose of this study was to identify clinical factors which may help in predicting the requirement of support of mechanical ventilation (MV) in patients with stroke. This was a prospective cohort study done at a tertiary referral center of India, from December 2008 to December 2009. All consecutive patients of ac...

journal_title：Journal of the neurological sciences

authors： Gupta P,Prasad K,Kumar A,Kumar P,Bhatia R,Tripathi M

更新日期：2014-02-15 00:00:00

abstract：OBJECTIVES:To examine whether quantitative analysis of the brainstem areas on magnetic resonance imaging (MRI) scans is useful for diagnosis as well as evaluation of disease activity in chronic progressive neuro-Behçet's disease (CPNB). METHODS:MRI scans in patients with acute neuro-Behçet's disease (ANB) (n = 10), CP...

journal_title：Journal of the neurological sciences

authors： Kikuchi H,Takayama M,Hirohata S

更新日期：2014-02-15 00:00:00

abstract：:A rapidly progressive motor-dominant neuropathy associated with IgM monoclonal antibody against gangliosides with disialosyl residues, GD3, GD1b, GT1b, and GQ1b, in a 60-year-old Japanese man with mantle cell lymphoma is reported. Plasma exchange and chemotherapy for mantle cell lymphoma were performed for the neuropa...

journal_title：Journal of the neurological sciences

authors： Mori A,Ueno Y,Kuroki T,Hoshino Y,Shimura H,Sekiguchi Y,Noguchi M,Hamada Y,Kusunoki S,Hattori N,Urabe T

更新日期：2014-02-15 00:00:00

abstract：:Sirtuin 2 (SIRT2) is a strong protein deacetylase, which is highly expressed in central nervous system. Recently, an association between SIRT2 rs10410544 polymorphism and late-onset Alzheimer's disease (LOAD) was found in the APOEε4-negative Caucasian population. To investigate the potential association between the rs...

journal_title：Journal of the neurological sciences

authors： Xia M,Yu JT,Miao D,Lu RC,Zheng XP,Tan L

更新日期：2014-01-15 00:00:00